GFRA3

Across TCGA patient cohorts, GFRA3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFRA3-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, PCNA, and PKC-b-II_pS660. Each is linked with GFRA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFRA3-to-partner and partner-to-GFRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by GFRA3-low versus GFRA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA3→partner) and Y-score (partner→GFRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.657	+3.321	.013	.010	3	1
UCEC	PCNA →	+0.310	+3.321	.006	.010	2	2
UCEC	PKC-b-II_pS660 →	-0.336	-3.000	.020	.036	3	1
SKCM	C-Raf_pS338 →	-0.160	-3.321	.014	.010	3	1
UCEC	p62 Lck ligand →	+0.515	+3.321	.002	.010	2	1
SKCM	JNK_pT183_Y185 →	-0.174	-3.321	.013	.010	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Acetyl-a-Tubulin-Lys40 by GFRA3 expression — UCEC

Explore this box plot interactively →