GFRA3

Across TCGA cell cohorts, GFRA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,343 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GFRA3-associated GO terms across cancer lineages are Aerobic electron transport chain, Spliceosomal conformational changes to generate catalytic conformation, and Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Each is linked with GFRA3 in more than 11 cancer types. Because this analysis shows association rather than direction, both GFRA3-to-partner and partner-to-GFRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aerobic electron transport chain grouped by GFRA3-low versus GFRA3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA3→partner) and Y-score (partner→GFRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Aerobic electron transport chain →	+0.083	+0.392	<.001	.007	3	11
LUNG_NSCLC_LUAD	Spliceosomal conformational changes to generate catalytic conformation →	+0.077	+0.254	<.001	.002	3	11
LUNG_NSCLC_LUAD	Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) →	+0.088	+0.229	<.001	.005	2	12
BREAST	RNA splicing, via transesterification reactions →	+0.075	+0.490	<.001	.001	2	11
BREAST	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.074	+0.474	<.001	.002	2	11
BREAST	mRNA splicing, via spliceosome →	+0.074	+0.474	<.001	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,343 associations by consensus.

Aerobic electron transport chain by GFRA3 expression — OVARY

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