GFRA3

Across TCGA cell cohorts, GFRA3 mutation is significantly associated with the RNA expression of many other genes, with 309 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GFRA3-associated genes across cancer lineages are SMR3B, GALP, and IL3. Each is linked with GFRA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFRA3-to-partner and partner-to-GFRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMR3B grouped by GFRA3-low versus GFRA3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA3→partner) and Y-score (partner→GFRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMR3B →	+0.030	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GALP →	+0.062	+5.201	<.001	.006	3	1
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 309 associations by consensus.

SMR3B by GFRA3 expression — BLOOD_Leukemia

Explore this box plot interactively →