GFRA1

Across TCGA patient cohorts, GFRA1 mutation is significantly associated with the RNA expression of many other genes, with 1,848 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFRA1-associated genes across cancer lineages are BUB3, PHF5A, and EIF2B2. Each is linked with GFRA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GFRA1-to-partner and partner-to-GFRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by GFRA1-low versus GFRA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA1→partner) and Y-score (partner→GFRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.387	+2.490	.001	.001	3	3
UCEC	PHF5A →	+0.498	+2.818	<.001	<.001	3	3
UCEC	EIF2B2 →	+0.287	+1.949	.006	.008	3	3
UCEC	SLF1 →	+0.472	+2.008	<.001	.001	3	3
UCEC	CCNB1 →	+0.615	+2.058	.001	<.001	3	3
UCEC	ACTR1A →	+0.273	+1.841	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,848 associations by consensus.

BUB3 by GFRA1 expression — UCEC

Explore this box plot interactively →