GFRA1

Across TCGA cell cohorts, GFRA1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GFRA1-associated genes across cancer lineages are OR52B6, KRTAP2-4, and RGSL1. Each is linked with GFRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFRA1-to-partner and partner-to-GFRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52B6 grouped by GFRA1-low versus GFRA1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA1→partner) and Y-score (partner→GFRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR52B6 →	+0.107	+3.791	<.001	.007	3	2
SKIN	KRTAP2-4 →	+0.048	+5.415	<.001	.004	3	1
OVARY	RGSL1 →	+0.053	+4.643	<.001	<.001	3	1
OVARY	TBATA →	+0.160	+3.700	<.001	.005	3	1
OVARY	CCR8 →	+0.110	+4.070	.005	.003	3	1
OVARY	CMA1 →	+0.043	+3.791	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR52B6 by GFRA1 expression — OVARY

Explore this box plot interactively →