GEN1

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, GEN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,779 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GEN1-associated proteins across cancer lineages are RRM2, SMC2, and SMC4. Each is linked with GEN1 in more than 8 cancer types. Because this analysis shows association rather than direction, both GEN1-to-partner and partner-to-GEN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GEN1 versus RRM2 in LUAD, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GEN1→partner) and Y-score (partner→GEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADRRM2 →+0.864+0.593<.001<.00139
LUADSMC2 →+0.578+0.611<.001<.00139
BRCASMC4 →+0.697+0.583<.001<.00139
OVKPNA2 →+0.617+0.715.001<.00139
GBMMCM2 →+0.874+0.739<.001<.00139
GBMMCM3 →+0.907+0.861<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 20,779 associations by consensus.

GEN1 vs RRM2 — LUAD

Per-sample scatter of GEN1 vs RRM2 in LUAD (Pearson r = 0.66).

Explore this scatter interactively →

Exploration