GEN1

Across TCGA patient cohorts, GEN1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,760 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GEN1-associated genes across cancer lineages are CKAP2L, MCM7, and XRCC2. Each is linked with GEN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GEN1-to-partner and partner-to-GEN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GEN1 versus CKAP2L in BRCA, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEN1→partner) and Y-score (partner→GEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CKAP2L →	+1.005	+0.501	<.001	<.001	3	4
GBM	MCM7 →	+0.719	+0.449	<.001	<.001	3	4
GBM	XRCC2 →	+1.841	+0.475	.006	<.001	3	4
HNSC	FAM72D →	+0.613	+0.443	.004	<.001	2	5
GBM	CEP76 →	+0.621	+0.333	.001	.002	3	3
UCEC	CUBN →	-1.037	-0.578	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,760 associations by consensus.

GEN1 vs CKAP2L — BRCA

Explore this scatter interactively →