GEMIN7-AS1

Across TCGA pan-cancer cohorts, GEMIN7-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GEMIN7-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher GEMIN7-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GEMIN7-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRP show a favorable association.

UVM, BRCA, and KIRP are the cancer types where GEMIN7-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.466	0.779	<.001	117	view →
BRCA	OS	Tertile	III,IV	0.908	0.703	<.001	59	view →
KIRP	DFS	Tertile	II,III,IV	0.833	0.228	.005	42	view →
PAAD	OS	Tertile	All	0.596	0.211	<.001	40	view →
LGG	DFS	Median	All	0.666	0.802	<.001	37	view →
BLCA	OS	Median	II,III,IV	0.776	0.657	.003	34	view →
UCEC	DFS	Quartile	III,IV	0.441	0.785	.010	18	view →
KIRC	DFS	Quartile	All	0.749	0.844	.021	16	view →
MESO	DFS	Tertile	IV	0.329	0.837	.007	15	view →
ACC	DFS	Median	All	0.245	0.598	.014	13	view →
CHOL	OS	Quartile	All	0.838	0.145	.014	12	view →
COAD	OS	Quartile	All	0.549	0.909	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GEMIN7-AS1–UVM (OS)

Open the UVM breakdown →