GEMIN5

Across TCGA cell cohorts, GEMIN5 mutation is significantly associated with the RNA expression of many other genes, with 242 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GEMIN5-associated genes across cancer lineages are KAAG1, OR6C75, and CYLC1. Each is linked with GEMIN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GEMIN5-to-partner and partner-to-GEMIN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KAAG1 grouped by GEMIN5-low versus GEMIN5-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN5→partner) and Y-score (partner→GEMIN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KAAG1 →	+0.059	+3.285	.002	.009	3	2
BLOOD_Myeloma	OR6C75 →	+0.016	+3.754	<.001	.002	3	2
PANCREAS	CYLC1 →	+0.006	+5.614	<.001	.002	3	1
BLOOD_Myeloma	DKK4 →	+0.031	+3.716	<.001	.005	3	1
BLOOD_Myeloma	LYZL4 →	+0.075	+3.285	<.001	.009	3	1
BLOOD_Myeloma	SSX5 →	+0.060	+4.000	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 242 associations by consensus.

KAAG1 by GEMIN5 expression — BLOOD_Myeloma

Explore this box plot interactively →