GEMIN4

Across TCGA patient cohorts, GEMIN4 protein abundance is significantly associated with the RNA expression of many other genes, with 9,062 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GEMIN4-associated genes across cancer lineages are CDCA5, CDC25A, and TRAIP. Each is linked with GEMIN4 in more than 6 cancer types. Because this analysis shows association rather than direction, both GEMIN4-to-partner and partner-to-GEMIN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GEMIN4 versus CDCA5 in BRCA, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN4→partner) and Y-score (partner→GEMIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA5 →	+1.080	+0.275	<.001	<.001	3	7
GBM	CDC25A →	+0.924	+0.240	<.001	<.001	3	7
UCEC	TRAIP →	+1.114	+0.282	<.001	<.001	3	7
BRCA	CDKN3 →	+0.885	+0.282	<.001	<.001	3	6
HNSC	VRK1 →	+1.134	+0.225	.001	<.001	3	6
UCEC	OIP5 →	+0.827	+0.250	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,062 associations by consensus.

GEMIN4 vs CDCA5 — BRCA

Explore this scatter interactively →