GDPD3

Across TCGA patient cohorts, GDPD3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDPD3-associated genes across cancer lineages are PCNA, eEF2, and EGFR_pY1068. Each is linked with GDPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDPD3-to-partner and partner-to-GDPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by GDPD3-low versus GDPD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDPD3→partner) and Y-score (partner→GDPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.300	+2.700	.002	.006	3	2
UCEC	eEF2 →	+0.381	+2.999	.018	.035	3	1
UCEC	EGFR_pY1068 →	-0.242	-2.000	.032	.032	3	1
UCEC	FoxM1 →	+0.243	+2.179	.037	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.180	-3.690	.001	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.228	-3.321	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PCNA by GDPD3 expression — UCEC

Explore this box plot interactively →