GDPD2

Across TCGA cell cohorts, GDPD2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GDPD2-associated genes across cancer lineages are IL31, MSGN1, and C10orf53. Each is linked with GDPD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDPD2-to-partner and partner-to-GDPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL31 grouped by GDPD2-low versus GDPD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDPD2→partner) and Y-score (partner→GDPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL31 →	+0.032	+4.977	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.177	+4.155	<.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.264	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

IL31 by GDPD2 expression — SKIN

Explore this box plot interactively →