GDI2

Across TCGA patient cohorts, GDI2 mutation is significantly associated with the RNA expression of many other genes, with 2,016 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDI2-associated genes across cancer lineages are GAGE2E, SEPTIN14P3, and OR6K6. Each is linked with GDI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDI2-to-partner and partner-to-GDI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE2E grouped by GDI2-low versus GDI2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDI2→partner) and Y-score (partner→GDI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	GAGE2E →	+0.113	+5.149	<.001	.003	3	2
BRCA	SEPTIN14P3 →	+0.208	+7.731	<.001	.009	3	2
BLCA	OR6K6 →	+0.091	+6.018	<.001	.002	3	2
BLCA	MIR199B →	+0.469	+5.329	<.001	.006	3	2
LIHC	NDUFB4P4 →	+0.152	+5.008	<.001	.004	3	2
LIHC	PYY3 →	+0.305	+8.499	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,016 associations by consensus.

GAGE2E by GDI2 expression — LIHC

Explore this box plot interactively →