GDF9

Across TCGA patient cohorts, GDF9 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,164 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GDF9-associated proteins across cancer lineages are ARHGEF1, PSTPIP1, and PTK2B. Each is linked with GDF9 in more than 4 cancer types. Because this analysis shows association rather than direction, both GDF9-to-partner and partner-to-GDF9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GDF9 versus ARHGEF1 in GBM, with a Pearson correlation of -0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF9→partner) and Y-score (partner→GDF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGEF1 →	-0.292	-0.487	<.001	<.001	3	5
GBM	PSTPIP1 →	-0.419	-0.332	.009	.003	3	4
LSCC	PTK2B →	-0.422	-0.379	<.001	<.001	3	4
GBM	RAC2 →	-0.637	-0.285	<.001	.003	3	4
LUAD	VSIR →	-0.379	-0.261	<.001	.009	2	5
LSCC	XPO1 →	+0.272	+0.426	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,164 associations by consensus.

GDF9 vs ARHGEF1 — GBM

Explore this scatter interactively →