GDF9

Across TCGA pan-cancer cohorts, GDF9 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GDF9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GDF9 RNA is repressed in tumor relative to normal tissue. In most cancer types GDF9 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where GDF9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GDF9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.478	<.001	10	view →
THCA	Male	III,IV	−0.759	<.001	9	view →
LIHC	Male	All	+0.308	<.001	9	view →
KICH	Female	II,III,IV	−1.120	<.001	6	view →
BRCA	All	All	+0.340	.005	6	view →
LUSC	All	All	+0.257	.001	5	view →
KIRP	All	All	−0.378	.001	2	view →
STAD	All	IV	−0.183	.030	2	view →
CHOL	All	All	+0.376	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GDF9–KIRC

Open the KIRC breakdown →