GDF9

Across TCGA patient cohorts, GDF9 mutation is significantly associated with the RNA expression of many other genes, with 1,589 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF9-associated genes across cancer lineages are ACTBP6, NFILZ, and SMIM10L2A. Each is linked with GDF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF9-to-partner and partner-to-GDF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTBP6 grouped by GDF9-low versus GDF9-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF9→partner) and Y-score (partner→GDF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ACTBP6 →	+0.079	+3.681	.003	<.001	3	2
CESC	NFILZ →	+0.063	+4.969	<.001	.004	3	2
UCEC	SMIM10L2A →	-0.555	-2.375	.005	.003	3	2
UCEC	CATSPERE →	-0.268	-2.390	.002	.003	3	2
UCEC	CIDECP1 →	+0.324	+3.892	<.001	<.001	3	2
UCEC	TLR5 →	-0.678	-2.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,589 associations by consensus.

ACTBP6 by GDF9 expression — BLCA

Explore this box plot interactively →