GDF9

Across TCGA patient cohorts, GDF9 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF9-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Annexin-1, and ATM. Each is linked with GDF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF9-to-partner and partner-to-GDF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by GDF9-low versus GDF9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF9→partner) and Y-score (partner→GDF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.523	-2.156	.001	.003	3	2
UCEC	Annexin-1 →	+0.563	+2.019	.004	.017	3	2
UCEC	ATM →	-0.521	-2.662	.002	<.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.362	-3.571	.010	.002	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.169	.005	.003	3	1
UCEC	FoxM1 →	+0.238	+2.662	.014	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p38-MAPK_pT180_Y182 by GDF9 expression — UCEC

Explore this box plot interactively →