GDF9

Across TCGA cell cohorts, GDF9 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GDF9-associated genes across cancer lineages are FAM240B and REG1B. Each is linked with GDF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF9-to-partner and partner-to-GDF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM240B grouped by GDF9-low versus GDF9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF9→partner) and Y-score (partner→GDF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM240B →	+0.029	+5.969	<.001	.001	3	1
LARGE_INTESTINE	REG1B →	+2.451	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

FAM240B by GDF9 expression — BLOOD_Leukemia

Explore this box plot interactively →