GDF7

Across TCGA patient cohorts, GDF7 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF7-associated genes across cancer lineages are Akt_pT308, 14-3-3_beta, and PRAS40_pT246. Each is linked with GDF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF7-to-partner and partner-to-GDF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by GDF7-low versus GDF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF7→partner) and Y-score (partner→GDF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.843	+2.321	.007	.035	3	2
UCEC	14-3-3_beta →	-0.111	-2.308	.027	.036	3	1
UCEC	PRAS40_pT246 →	+0.226	+2.335	.008	.020	3	1
UCEC	Annexin-1 →	+0.714	+2.321	.006	.035	3	1
UCEC	CD49b →	-0.308	-2.308	.031	.036	3	1
UCEC	Heregulin →	-0.159	-3.169	.010	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Akt_pT308 by GDF7 expression — UCEC

Explore this box plot interactively →