GDF5

Across TCGA patient cohorts, GDF5 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,614 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GDF5-associated proteins across cancer lineages are VCAN_S2116, KANK2, and PALM2AKAP2. Each is linked with GDF5 in more than 3 cancer types. Because this analysis shows association rather than direction, both GDF5-to-partner and partner-to-GDF5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GDF5 versus VCAN_S2116 in HNSC, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF5→partner) and Y-score (partner→GDF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VCAN_S2116 →	+1.004	+0.473	<.001	.002	3	4
COAD	KANK2 →	+0.430	+0.172	<.001	<.001	3	4
COAD	PALM2AKAP2 →	+0.342	+0.242	<.001	.001	3	3
LUAD	MICU1 →	-0.483	-0.604	<.001	<.001	3	3
BRCA	NCK1 →	+0.315	+0.689	<.001	<.001	3	3
COAD	PRRC1 →	-0.252	-0.175	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,614 associations by consensus.

GDF5 vs VCAN_S2116 — HNSC

Explore this scatter interactively →