GDF5

Across TCGA patient cohorts, GDF5 protein abundance is significantly associated with the RNA expression of many other genes, with 3,430 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GDF5-associated genes across cancer lineages are LMOD1, SYNPO2, and DES. Each is linked with GDF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both GDF5-to-partner and partner-to-GDF5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GDF5 versus LMOD1 in UCEC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF5→partner) and Y-score (partner→GDF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMOD1 →	+1.573	+1.051	<.001	<.001	3	3
UCEC	SYNPO2 →	+1.171	+0.830	<.001	.006	3	3
CCRCC	DES →	+2.975	+0.539	<.001	<.001	3	3
UCEC	MYOCD →	+1.101	+0.891	.001	.002	3	3
GBM	LAMA2 →	+1.268	+0.584	.001	.007	3	3
PDAC	CAV1 →	+1.736	+1.122	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,430 associations by consensus.

GDF5 vs LMOD1 — UCEC

Explore this scatter interactively →