GDF11

Across TCGA patient cohorts, GDF11 mutation is significantly associated with the RNA expression of many other genes, with 387 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF11-associated genes across cancer lineages are RN7SKP188, SUMO2P5, and RPL30P11. Each is linked with GDF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF11-to-partner and partner-to-GDF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP188 grouped by GDF11-low versus GDF11-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF11→partner) and Y-score (partner→GDF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP188 →	+0.063	+4.492	.001	.005	3	2
BLCA	SUMO2P5 →	+0.082	+4.296	<.001	.006	3	2
UCEC	RPL30P11 →	+0.235	+3.649	.002	.001	3	2
COAD	RPL5P31 →	+0.231	+4.446	<.001	.006	3	2
COAD	LINC01707 →	+0.215	+4.693	<.001	.007	3	2
COAD	COX6B1P7 →	+0.467	+5.392	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 387 associations by consensus.

RN7SKP188 by GDF11 expression — BLCA

Explore this box plot interactively →