GDF10

Across TCGA cell cohorts, GDF10 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GDF10-associated genes across cancer lineages are INSRR, GGTLC2, and SLC22A7. Each is linked with GDF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF10-to-partner and partner-to-GDF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INSRR grouped by GDF10-low versus GDF10-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF10→partner) and Y-score (partner→GDF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	INSRR →	+0.035	+4.142	<.001	.008	3	2
SKIN	GGTLC2 →	+0.029	+4.688	<.001	<.001	3	1
SKIN	SLC22A7 →	+0.022	+4.437	<.001	.004	3	1
SKIN	MYL3 →	+0.077	+4.054	<.001	.004	3	1
SKIN	ANKRD30BL →	+0.072	+3.684	<.001	.006	3	1
SKIN	CLEC4E →	+0.115	+4.347	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

INSRR by GDF10 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →