GDF10

Across TCGA pan-cancer cohorts, GDF10 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GDF10’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GDF10 RNA is repressed in tumor relative to normal tissue. In most cancer types GDF10 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and BLCA are the cancer types where GDF10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GDF10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−4.005	<.001	11	view →
LUAD	Male	III,IV	−3.931	<.001	11	view →
BLCA	Male	IV	−2.422	<.001	11	view →
HNSC	All	IV	−1.532	<.001	11	view →
LUSC	Female	II,III,IV	−4.961	<.001	9	view →
BRCA	All	II,III,IV	−3.003	<.001	6	view →
COAD	All	III,IV	−0.530	.007	5	view →
UCEC	All	All	−1.324	<.001	4	view →
LIHC	All	All	+0.364	.003	4	view →
READ	All	All	−1.031	.002	2	view →
PRAD	All	All	−1.010	<.001	2	view →
STAD	All	All	−0.778	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GDF10–THCA

Open the THCA breakdown →