GDE1

Across TCGA pan-cancer cohorts, GDE1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GDE1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GDE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GDE1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where GDE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.661	0.862	.002	38	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	6	view →
UCEC	DFS	Median	All	0.950	1.000	.035	6	view →
LSCC	DFS	Median	II,III,IV	0.575	0.831	.033	6	view →
LUAD	DFS	Median	All	0.649	0.927	.021	5	view →
HNSC	OS	Median	All	0.803	0.629	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GDE1–PDAC (DFS)

Open the PDAC breakdown →