GDE1

Across TCGA pan-cancer cohorts, GDE1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GDE1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GDE1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GDE1 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

KIRP, COAD, and LIHC are the cancer types where GDE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GDE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.750	<.001	11	view →
COAD	Female	All	−0.693	<.001	10	view →
LIHC	All	II,III,IV	+0.588	<.001	8	view →
KIRC	Male	II,III,IV	−0.413	<.001	7	view →
BRCA	Female	All	+0.467	<.001	6	view →
CHOL	All	All	+1.281	<.001	5	view →
READ	All	All	−0.690	<.001	5	view →
KICH	All	All	+0.545	<.001	5	view →
LUSC	All	III,IV	−0.549	.006	3	view →
STAD	All	II,III,IV	+0.490	.003	3	view →
UCEC	All	All	+0.400	.036	2	view →
LUAD	All	All	+0.209	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GDE1–KIRP

Open the KIRP breakdown →