GDE1

Across TCGA patient cohorts, GDE1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDE1-associated genes across cancer lineages are G6PD, Caspase-8, and Notch1. Each is linked with GDE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDE1-to-partner and partner-to-GDE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PD grouped by GDE1-low versus GDE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDE1→partner) and Y-score (partner→GDE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	G6PD →	-0.368	-2.986	.038	.035	3	1
UCEC	Caspase-8 →	-0.325	-3.000	.018	.036	3	1
UCEC	Notch1 →	+0.159	+3.169	.039	.020	2	1
UCEC	Tuberin →	+0.474	+3.009	.001	.019	2	1
UCEC	eIF4G →	+0.398	+3.169	.019	.020	1	1
UCEC	C-Raf →	+0.161	+3.169	.041	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

G6PD by GDE1 expression — UCEC

Explore this box plot interactively →