GDAP1L1

Across TCGA patient cohorts, GDAP1L1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDAP1L1-associated genes across cancer lineages are RAD51, Rad50, and ERK2. Each is linked with GDAP1L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GDAP1L1-to-partner and partner-to-GDAP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by GDAP1L1-low versus GDAP1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDAP1L1→partner) and Y-score (partner→GDAP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.094	+2.115	.045	.017	3	3
SKCM	Rad50 →	-0.324	-2.987	.040	.035	3	2
UCEC	ERK2 →	+0.205	+1.874	.001	.002	3	2
UCEC	Ku80 →	+0.271	+1.598	<.001	.006	3	2
UCEC	PCNA →	+0.298	+2.201	<.001	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.104	-2.222	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

RAD51 by GDAP1L1 expression — UCEC

Explore this box plot interactively →