GDAP1L1

Across TCGA pan-cancer cohorts, GDAP1L1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GDAP1L1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where GDAP1L1 RNA is repressed in tumor relative to normal tissue. In most cancer types GDAP1L1 is over-expressed in tumor, although a few such as UCEC and THCA show the opposite, repressed pattern.

UCEC, KIRP, and THCA are the cancer types where GDAP1L1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GDAP1L1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−0.521	<.001	8	view →
KIRP	All	All	+0.549	<.001	5	view →
THCA	Male	III,IV	−0.277	<.001	4	view →
STAD	Male	IV	−0.185	.017	4	view →
KICH	All	All	+0.477	.010	3	view →
CHOL	All	All	+0.121	<.001	3	view →
LUAD	All	All	+0.153	.013	2	view →
BRCA	All	All	+0.137	.047	2	view →
LIHC	Female	All	+0.024	.011	2	view →
LUSC	Male	III,IV	−0.080	.009	1	view →
HNSC	All	All	+0.028	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GDAP1L1–UCEC

Open the UCEC breakdown →