GCSIR

Across TCGA patient cohorts, GCSIR RNA expression is significantly associated with the go_rna of many other GO terms, with 7,072 significant associations in total. STAD shows the largest number of these associations.

The most reproducible GCSIR-associated GO terms across cancer lineages are ERAD pathway, Glycerophospholipid biosynthetic process, and Regulation of double-strand break repair. Each is linked with GCSIR in more than 18 cancer types. Because this analysis shows association rather than direction, both GCSIR-to-partner and partner-to-GCSIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by GCSIR-low versus GCSIR-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCSIR→partner) and Y-score (partner→GCSIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	ERAD pathway →	+0.077	+0.081	<.001	.001	3	19
STAD	Glycerophospholipid biosynthetic process →	+0.058	+0.074	<.001	<.001	3	19
STAD	Regulation of double-strand break repair →	+0.059	+0.066	<.001	<.001	3	18
ESCA	Negative regulation of transferase activity →	+0.061	+0.086	<.001	.001	3	18
STAD	Vesicle localization →	+0.057	+0.075	<.001	<.001	3	18
STAD	Regulation of intracellular protein transport →	+0.064	+0.068	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,072 associations by consensus.

ERAD pathway by GCSIR expression — ESCA

Explore this box plot interactively →