GCSIR

Across TCGA pan-cancer cohorts, GCSIR RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GCSIR’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GCSIR RNA is repressed in tumor relative to normal tissue. In most cancer types GCSIR is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, LUAD, and KICH are the cancer types where GCSIR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GCSIR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.191	<.001	11	view →
LUAD	All	All	+0.024	<.001	6	view →
KICH	Male	All	−0.041	<.001	4	view →
READ	All	II,III,IV	−0.175	.027	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

GCSIR–COAD

Open the COAD breakdown →