GCSAML

Across TCGA patient cohorts, GCSAML mutation is significantly associated with the RNA expression of many other genes, with 1,316 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCSAML-associated genes across cancer lineages are JOSD1, GLA, and GMDS. Each is linked with GCSAML in more than 2 cancer types. Because this analysis shows association rather than direction, both GCSAML-to-partner and partner-to-GCSAML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JOSD1 grouped by GCSAML-low versus GCSAML-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCSAML→partner) and Y-score (partner→GCSAML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	JOSD1 →	+0.309	+1.459	.009	.006	3	2
SKCM	GLA →	+0.407	+1.662	<.001	.001	3	2
SKCM	GMDS →	+0.276	+2.751	.009	.002	3	2
LUAD	MIR128-1 →	+0.593	+3.983	<.001	.001	3	2
UCEC	TMEM251 →	+0.646	+3.343	<.001	.005	3	2
UCEC	PPIP5K1 →	+0.399	+2.625	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,316 associations by consensus.

JOSD1 by GCSAML expression — SKCM

Explore this box plot interactively →