GCSAML

Across TCGA pan-cancer cohorts, GCSAML RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GCSAML’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GCSAML RNA is repressed in tumor relative to normal tissue. In most cancer types GCSAML is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and LUSC are the cancer types where GCSAML tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GCSAML RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.624	<.001	12	view →
BLCA	Male	IV	−1.172	<.001	10	view →
LUSC	Female	II,III,IV	−1.362	<.001	8	view →
LUAD	All	II,III,IV	−0.898	<.001	8	view →
READ	All	All	−0.628	.003	7	view →
UCEC	All	All	−0.462	<.001	6	view →
LIHC	All	II,III,IV	+0.039	.008	4	view →
KIRP	All	All	+0.277	.017	3	view →
STAD	All	II,III,IV	−0.206	.021	3	view →
KICH	Male	All	−0.145	.005	3	view →
KIRC	All	All	+0.122	.001	3	view →
BRCA	All	III,IV	−0.317	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GCSAML–COAD

Open the COAD breakdown →