GCSAML

Across TCGA patient cohorts, GCSAML mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCSAML-associated genes across cancer lineages are eEF2, ACC1, and Caspase-8. Each is linked with GCSAML in more than 2 cancer types. Because this analysis shows association rather than direction, both GCSAML-to-partner and partner-to-GCSAML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GCSAML-low versus GCSAML-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCSAML→partner) and Y-score (partner→GCSAML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.381	+3.000	.022	.036	3	2
UCEC	ACC1 →	+0.349	+2.820	.039	.035	3	2
UCEC	Caspase-8 →	-0.243	-3.143	.038	.018	3	2
SKCM	ACC_pS79 →	+0.212	+2.115	.038	.017	3	2
SKCM	c-Met →	-0.112	-1.982	.029	.002	3	2
UCEC	ERK2 →	+0.231	+2.999	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eEF2 by GCSAML expression — UCEC

Explore this box plot interactively →