GCSAML

Across TCGA cell cohorts, GCSAML mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GCSAML-associated genes across cancer lineages are C6orf118, SSMEM1, and NPY2R. Each is linked with GCSAML in more than 1 cancer types. Because this analysis shows association rather than direction, both GCSAML-to-partner and partner-to-GCSAML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by GCSAML-low versus GCSAML-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCSAML→partner) and Y-score (partner→GCSAML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.122	+3.115	<.001	.004	3	1
LARGE_INTESTINE	SSMEM1 →	+0.025	+3.029	<.001	.006	3	1
LARGE_INTESTINE	NPY2R →	+0.003	+3.217	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TECRL →	+0.012	+3.562	<.001	.002	3	1
LARGE_INTESTINE	OR5V1 →	+0.005	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C6orf118 by GCSAML expression — LARGE_INTESTINE

Explore this box plot interactively →