GCSAM

Across TCGA pan-cancer cohorts, GCSAM Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GCSAM data layer compared with 27 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher GCSAM Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GCSAM expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

SKCM and BLCA are the cancer types where GCSAM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.475	0.736	.049	2	view →
BLCA	OS	Median	III,IV	1.000	0.351	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

GCSAM–SKCM (OS)

Open the SKCM breakdown →