GCSAM

Across TCGA pan-cancer cohorts, GCSAM RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GCSAM’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GCSAM RNA is repressed in tumor relative to normal tissue. In most cancer types GCSAM is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and HNSC are the cancer types where GCSAM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GCSAM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.678	<.001	9	view →
COAD	Female	II,III,IV	−0.651	<.001	8	view →
HNSC	Male	All	+0.609	<.001	8	view →
LUAD	All	III,IV	−0.516	<.001	6	view →
KICH	Male	All	−0.506	.013	4	view →
UCEC	All	All	−0.313	.005	4	view →
CHOL	All	All	+1.421	<.001	3	view →
BRCA	All	All	+0.266	.024	3	view →
STAD	Female	All	+0.834	.035	2	view →
PRAD	All	All	−0.233	.014	2	view →
KIRC	Female	IV	−0.478	.008	1	view →
LUSC	Male	All	+0.389	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GCSAM–THCA

Open the THCA breakdown →