GCSAM

Across TCGA patient cohorts, GCSAM mutation is significantly associated with the RNA expression of many other genes, with 690 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCSAM-associated genes across cancer lineages are LINC01043, PGBD4P2, and PTPRJ. Each is linked with GCSAM in more than 1 cancer types. Because this analysis shows association rather than direction, both GCSAM-to-partner and partner-to-GCSAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01043 grouped by GCSAM-low versus GCSAM-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCSAM→partner) and Y-score (partner→GCSAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01043 →	+0.009	+5.410	.009	.005	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
UCEC	PTPRJ →	+0.574	+2.098	.007	.003	3	1
UCEC	TMEM138 →	+0.270	+3.258	.003	<.001	3	1
UCEC	GPHA2 →	-0.552	-3.785	.004	<.001	3	1
UCEC	MRPL49 →	+0.540	+2.923	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 690 associations by consensus.

LINC01043 by GCSAM expression — LUAD

Explore this box plot interactively →