GCSAM

Across TCGA cell cohorts, GCSAM RNA expression is significantly associated with the go_rna of many other GO terms, with 5,023 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GCSAM-associated GO terms across cancer lineages are Post-transcriptional gene silencing, Regulation of intracellular protein transport, and Microtubule nucleation. Each is linked with GCSAM in more than 9 cancer types. Because this analysis shows association rather than direction, both GCSAM-to-partner and partner-to-GCSAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-transcriptional gene silencing grouped by GCSAM-low versus GCSAM-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GCSAM→partner) and Y-score (partner→GCSAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Post-transcriptional gene silencing →	+0.089	+0.567	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of intracellular protein transport →	+0.077	+0.781	.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Microtubule nucleation →	+0.085	+0.861	.001	.001	3	9
LARGE_INTESTINE	Rho protein signal transduction →	+0.106	+0.584	<.001	<.001	3	9
LARGE_INTESTINE	Negative regulation of supramolecular fiber organization →	+0.051	+0.481	.001	.001	3	9
BREAST	Regulation of establishment or maintenance of cell polarity →	+0.095	+0.552	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,023 associations by consensus.

Post-transcriptional gene silencing by GCSAM expression — PANCREAS

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