GCM2

Across TCGA patient cohorts, GCM2 mutation is significantly associated with the RNA expression of many other genes, with 1,440 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCM2-associated genes across cancer lineages are RNU6-1286P, MIR874, and RNU6-200P. Each is linked with GCM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GCM2-to-partner and partner-to-GCM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1286P grouped by GCM2-low versus GCM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCM2→partner) and Y-score (partner→GCM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1286P →	+0.279	+5.831	<.001	<.001	3	3
STAD	MIR874 →	+0.520	+4.167	.001	.004	3	3
SKCM	RNU6-200P →	+0.073	+3.903	<.001	.007	3	3
BRCA	MIR3135A →	+0.646	+4.924	<.001	.002	3	2
SKCM	OR5B15P →	+0.010	+3.903	<.001	.007	3	2
OV	MIR4803 →	+0.565	+5.063	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,440 associations by consensus.

RNU6-1286P by GCM2 expression — COAD

Explore this box plot interactively →