GCLM

Across TCGA patient cohorts, GCLM mutation is significantly associated with the RNA expression of many other genes, with 157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCLM-associated genes across cancer lineages are SNORA36C, RNU6-370P, and LINC00350. Each is linked with GCLM in more than 2 cancer types. Because this analysis shows association rather than direction, both GCLM-to-partner and partner-to-GCLM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORA36C grouped by GCLM-low versus GCLM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCLM→partner) and Y-score (partner→GCLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORA36C →	+0.360	+3.966	<.001	<.001	3	3
BRCA	RNU6-370P →	+0.320	+5.070	.009	.008	3	2
BRCA	LINC00350 →	+0.111	+6.112	.002	.002	3	2
BRCA	GSTA11P →	+0.154	+5.070	<.001	.008	3	2
BLCA	OR11H2 →	+0.049	+5.588	<.001	.004	3	2
BLCA	MTHFD2P3 →	+0.202	+6.444	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 157 associations by consensus.

SNORA36C by GCLM expression — UCEC

Explore this box plot interactively →