GCLC

Across TCGA patient cohorts, GCLC mutation is significantly associated with the RNA expression of many other genes, with 3,057 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCLC-associated genes across cancer lineages are LRRC37B, MAN2A1-DT, and GTSE1-DT. Each is linked with GCLC in more than 2 cancer types. Because this analysis shows association rather than direction, both GCLC-to-partner and partner-to-GCLC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC37B grouped by GCLC-low versus GCLC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCLC→partner) and Y-score (partner→GCLC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LRRC37B →	+0.285	+2.212	.007	<.001	3	3
UCEC	MAN2A1-DT →	+0.260	+2.147	.007	.009	3	2
UCEC	GTSE1-DT →	+0.393	+3.079	<.001	<.001	3	2
BRCA	CSN1S2AP →	+1.302	+5.148	<.001	.008	3	2
LUAD	RPSAP62 →	+0.070	+4.076	<.001	.004	3	2
UCEC	PGAP2 →	+0.354	+2.212	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,057 associations by consensus.

LRRC37B by GCLC expression — UCEC

Explore this box plot interactively →