GCK

Across TCGA patient cohorts, GCK mutation is significantly associated with the RNA expression of many other genes, with 1,190 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCK-associated genes across cancer lineages are FEN1, RSPO4, and WFDC2. Each is linked with GCK in more than 2 cancer types. Because this analysis shows association rather than direction, both GCK-to-partner and partner-to-GCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEN1 grouped by GCK-low versus GCK-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCK→partner) and Y-score (partner→GCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FEN1 →	+0.839	+3.471	<.001	.002	3	3
UCEC	RSPO4 →	-1.038	-3.568	.005	.002	3	3
UCEC	WFDC2 →	-1.621	-2.393	<.001	.003	3	3
BLCA	RNU6-291P →	+0.321	+3.758	.001	.008	3	2
READ	NPLP1 →	+0.291	+5.421	<.001	.005	3	2
LUAD	GTSE1 →	+0.838	+3.459	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,190 associations by consensus.

FEN1 by GCK expression — LUAD

Explore this box plot interactively →