GCK

Across TCGA cell cohorts, GCK mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCK-associated genes across cancer lineages are CA5A, TARM1, and PAX1. Each is linked with GCK in more than 1 cancer types. Because this analysis shows association rather than direction, both GCK-to-partner and partner-to-GCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CA5A grouped by GCK-low versus GCK-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCK→partner) and Y-score (partner→GCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1
URINARY_TRACT	TARM1 →	+0.026	+5.087	<.001	.004	3	1
BLOOD_Leukemia	PAX1 →	+0.042	+4.060	<.001	.003	3	1
BLOOD_Leukemia	CST8 →	+0.037	+4.384	<.001	.006	3	1
BLOOD_Leukemia	BTBD16 →	+0.122	+3.959	<.001	.005	3	1
BLOOD_Leukemia	RHCG →	+0.103	+3.729	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

CA5A by GCK expression — URINARY_TRACT

Explore this box plot interactively →