GCDH

Across TCGA pan-cancer cohorts, GCDH mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GCDH data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GCDH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GCDH expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, UCEC, and LSCC are the cancer types where GCDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.922	.017	60	view →
UCEC	OS	Tertile	All	0.834	1.000	.002	22	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.721	.003	21	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.221	.017	13	view →
HNSC	DFS	Median	IV	0.557	0.803	.008	11	view →
PDAC	OS	Quartile	III,IV	1.000	0.654	.005	10	view →
OV	DFS	Median	All	0.647	0.884	.048	4	view →
CCRCC	OS	Tertile	III,IV	1.000	0.780	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GCDH–COAD (DFS)

Open the COAD breakdown →