GCDH

Across TCGA patient cohorts, GCDH protein abundance is significantly associated with the RNA expression of many other genes, with 13,455 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GCDH-associated genes across cancer lineages are PLAUR, PLAU, and PLK2. Each is linked with GCDH in more than 5 cancer types. Because this analysis shows association rather than direction, both GCDH-to-partner and partner-to-GCDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GCDH versus PLAUR in HNSC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCDH→partner) and Y-score (partner→GCDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLAUR →	-0.806	-0.211	<.001	<.001	3	6
GBM	PLAU →	-1.182	-0.266	<.001	.001	3	6
HNSC	PLK2 →	-0.869	-0.247	<.001	<.001	3	6
LSCC	LOXL2 →	-1.149	-0.284	<.001	<.001	3	5
LSCC	SPOCD1 →	-0.792	-0.265	<.001	<.001	3	5
OV	ANXA5 →	-0.761	-0.418	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,455 associations by consensus.

GCDH vs PLAUR — HNSC

Explore this scatter interactively →