GCDH

Across TCGA patient cohorts, GCDH mutation is significantly associated with the RNA expression of many other genes, with 991 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCDH-associated genes across cancer lineages are TRAJ22, LMF2, and SLC25A1. Each is linked with GCDH in more than 1 cancer types. Because this analysis shows association rather than direction, both GCDH-to-partner and partner-to-GCDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ22 grouped by GCDH-low versus GCDH-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCDH→partner) and Y-score (partner→GCDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TRAJ22 →	+0.514	+4.934	.001	.002	3	2
SKCM	LMF2 →	+0.607	+3.182	.002	.009	3	2
UCEC	SLC25A1 →	+0.450	+2.246	.002	.005	3	2
UCEC	FBXO7 →	+0.378	+2.021	.002	.001	3	2
UCEC	SBF1 →	+0.570	+2.413	<.001	<.001	3	2
UCEC	VAC14 →	+0.437	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 991 associations by consensus.

TRAJ22 by GCDH expression — CESC

Explore this box plot interactively →