GCDH

Across TCGA patient cohorts, GCDH mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCDH-associated genes across cancer lineages are Rab25, VHL, and ATM. Each is linked with GCDH in more than 1 cancer types. Because this analysis shows association rather than direction, both GCDH-to-partner and partner-to-GCDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by GCDH-low versus GCDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCDH→partner) and Y-score (partner→GCDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.349	-2.000	.006	.030	3	2
UCEC	VHL →	-0.749	-2.222	.004	.010	3	2
UCEC	ATM →	-0.427	-3.308	.014	.009	3	2
UCEC	Beclin →	+0.130	+2.584	<.001	.001	3	2
UCEC	eIF4E →	+0.166	+1.678	.040	.023	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.528	+2.584	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Rab25 by GCDH expression — UCEC

Explore this box plot interactively →