GCC2

Across TCGA patient cohorts, GCC2 protein abundance is significantly associated with the RNA expression of many other genes, with 18,082 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GCC2-associated genes across cancer lineages are XBP1, MLPH, and TMEM144. Each is linked with GCC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both GCC2-to-partner and partner-to-GCC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GCC2 versus XBP1 in BRCA, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCC2→partner) and Y-score (partner→GCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XBP1 →	+2.072	+0.437	<.001	<.001	3	6
BRCA	MLPH →	+2.455	+0.291	<.001	<.001	3	6
BRCA	TMEM144 →	+1.023	+0.232	<.001	<.001	3	6
BRCA	C9orf152 →	+1.830	+0.303	<.001	<.001	3	6
UCEC	TOM1L1 →	+0.630	+0.346	<.001	<.001	3	6
OV	CHRAC1 →	-0.469	-0.201	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,082 associations by consensus.

GCC2 vs XBP1 — BRCA

Explore this scatter interactively →