GCC2

Across TCGA pan-cancer cohorts, GCC2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GCC2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GCC2 RNA is repressed in tumor relative to normal tissue. In most cancer types GCC2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and UCEC are the cancer types where GCC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GCC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.573	<.001	8	view →
KICH	Female	II,III,IV	−1.671	<.001	7	view →
UCEC	All	All	−0.664	.001	6	view →
CHOL	Male	All	+2.048	<.001	5	view →
LUSC	All	All	−0.413	<.001	5	view →
COAD	Female	All	−0.775	.001	4	view →
STAD	All	II,III,IV	+0.705	.001	4	view →
PAAD	Male	All	+0.620	.012	4	view →
LIHC	All	All	+0.383	.003	4	view →
KIRP	All	IV	+0.705	.045	2	view →
PRAD	All	All	+0.388	.001	2	view →
KIRC	Male	III,IV	−0.360	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GCC2–THCA

Open the THCA breakdown →